HVAC Design for Clean Rooms - Hospitals & Pharma 1. Clean Room Classifications (ISO & GMP) Classification Max. Particles ≥0.5µm / m³ Typical Use ISO 5/ Class 100 3,520 OT, IV Room ISO 7/ Class 10,000 352,000 Compounding Area ISO 8/ Class 100,000 3,520,000 Packing Area 2. Air Changes Per Hour (ACH) Room Type Recommended ACH Operation Theater (OT) 20-25 ICU/NICU 15-20 Cleanrooms ISO 7 60-90 Cleanrooms ISO 8 15-20 Example: Room Volume = 5 m x 5 m x 3 m = 75 m³ ACH = 25 Airflow = (25 x 75)/60 = 31.25 CMM ≈ 1100 CFM 3. HEPA Filter Design HEPA Efficiency: ≥99.97% @ 0.3µm 1 HEPA filter (24"x 24") handles ~500 CFM OT needing 1000 CFM Use 2 filters 4. Room Pressure Differential Area Type Pressure Difference OT vs Corridor +10 to +15 Pa ICU vs Corridor +5 to +10 Pa Isolation Room -10 to-15 Pa 5. Laminar Airflow (LAF) Velocity: 90 ± 20 ft/min (0.45 ± 0.05 m/s) Area: ~9 ft x 6 ft above OT table 6. Humidity & Temperature Control Area Temp (°C) RH (%) OT 21-24 50-60 ICU / Pa...
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